Snaggle, I'm going to try simplifying my argument by using two Chevy engines. Since I'll be avoiding the Pontiac's, maybe then you can avoid being so darn one-sided... ;)
There have been plenty of articles comparing the 454 Chevy Big Block, to the 454 (Motown inspired) Chevy Small Block. With all things being equal, the engines produced similar numbers on the dyno (as expected), but when it came time to bigger valves, hogging out the heads, and bumping up compression levels, the small block (smaller block, literally) was now very very limited (in comparison to the Big Block)...
The bigger the block, the more bore and stroke that can be utilized. The bigger the heads, the more flow, duration and lift that can be taken advatnge of. It's not rocket science, you know... ;)